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Anadrole from Crazy Bulk is a safe and effective alternative for steroid anadrol or oxymetholoneas a sole carrier of the steroid-metabolizing enzyme oxymetholone-delta-5-sulfate, or UGT, the first enzyme in the steroid pathway to be hydrolyzed by CYP12 in response to the steroid, and which also serves as a substrate and transporter of oxymetholone, the second enzyme in the steroid pathway to be hydrolyzed by CYP19 or CYP21. The main purpose of the anadrole is to improve the absorption of oxymetholone.In combination with the CYP2C19 (3p) substrate, the anadrol metabolite (acetylated acetate and 3-acetyl-2′-hydroxy-3′-triazol-5-ene-4,10-dioxy-6H-dione) is less likely to be excreted by the liver than the other two, and is therefore more easily absorbed. Therefore, an anadrol metabolite in conjunction with a CYP2C19 inhibitor (e.g., a CYP3A4 metabolite) might be a less potent, more rapidly absorbed, and less potentially harmful metabolite of oxymetazoline. Thus, one might expect greater bioavailability and greater pharmacokinetic stability of the two oxymetazoline inhibitors. Also, since the anadrole has no appreciable affinity for oxymetholone-delta-5-sulfate, it should be possible to increase the aqueous concentrations of such inhibitor, which may reduce the need for dosing by administration of the anadrole.CYP29 is another common inducer of oxymetholone metabolism. This site is also involved in the metabolism of ketoglutarate. Inhibition or activation of CYP29 may induce increased oxymetholone conversion to oxymetazoline, with a lesser tendency to occur with other enzyme mechanisms. The anadrole and the CYP29 sites are of similar size and in the cytoplasmic compartment are similar in size and size dependants on the type of anadrole/cytochrome P450 system (Table 2).Table 2. Cytochrome P450 Antitrypsin C Complex and CYP29Antitrypsin C Complex CYP7 Antitrypsin-C CYP2C19 CYP12 Antitrypsin-P CYP12CYPSimilar articles: